The role of endocytic trafficking in antigen T cell receptor activation
This review article summarizes the molecular mechanisms of T cell receptor (TCR) #endocytosis and recycling, both in steady state and after T cell activation. It also discusses the experimental evidence in favor of endosomal TCR signaling and its possible consequences for T cell activation. #immunology #biology Abstract Antigen T cell receptors (TCR) recognize antigenic peptides displayed by the major histocompatibility complex (pMHC) and play a critical role in T cell activa