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Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.

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CRISPR-Cas12a: Functional overview and applications

#openaccess #genetherapy #CRISPR Prokaryotes have developed an adaptive immune system called Clustered regularly interspaced short palindromic repeats (CRISPR) to combat attacks by foreign mobile genetic elements (MGEs) such as plasmids and phages. In the past decade, the widely characterized CRISPR-Cas9 enzyme has been redesigned to trigger a genome editing revolution. Class II type V CRISPR-Cas12a is a new RNA guided endonuclease that has been recently harnessed as an alter

Artificial intelligence approach fighting COVID19 with repurposing drugs

#COVID19 #openaccess #coronavirus #ArtificialIntelligence #AI Background The ongoing COVID-19 pandemic has caused more than 193,825 deaths during the past few months. A quick-to-be-identified cure for the disease will be a therapeutic medicine that has prior use experiences in patients in order to resolve the current pandemic situation before it could become worsening. Artificial intelligence (AI) technology is hereby applied to identify the marketed drugs with potential for

Development of humoral immunity

#openaccess #immunology Special issue with four review articles describing current understanding of the development and biology of B lymphocytes. (All articles are free.)

Development of humoral immunity

#immunology #openaccess #HumoralImmunity #development This special issue of Biomedical Journal contains 4 review articles describing our current understanding of the development & biology of B lymphocytes. (All articles are free)

Development of humoral immunity

#immunology #openaccess All articles are free This issue of Biomedical Journal contains four review articles describing our current understanding of the development and biology of B lymphocytes. The first review article, by Dr. Ana Cumano and her colleagues [1], describes how the B lymphocyte compartment develops during embryogenesis, and analyzes the contribution of successive waves of progenitors from the yolk sac, aorta-gonads-mesonephros, fetal liver and bone marrow in t

Tissue-specific diversity of bacterial endophytes in Mexican husk tomato plants

Tissue-specific diversity of bacterial endophytes in Mexican husk tomato plants (Physalis ixocarpa Brot. ex Horm.), & screening for their multiple plant growth-promoting activities #openaccess #agriculture #microbiology The endophytic bacterial diversity of root, stem, and leaf tissues of Mexican husk tomato plants (Physalis ixocarpa) was compared and deciphered, and screened for their plant growth-promoting activity and antagonism against fungal phytopathogens. Total 315 iso

The Role of Medicine & Technology in Shaping the Future of Oral Health.

This commentary describes the changes taking place in #dentistry and speculates on improvements that could happen soon. Advances in health care will have an impact on the integration and delivery of oral care; conversely, there is growing acceptance that #oralhealth impacts systemic health. Technological innovations are changing the face of medical care and are quickly becoming integrated into dentistry. Advances in novel antimicrobials, #genomics, #robotics and #artificialin

Food safety in the 21st century

Food is essential to life, hence #food #safety is a basic human right. Billons of people in the world are at risk of unsafe food. Many millions become sick while hundreds of thousand die yearly. The food chain starts from farm to fork/plate while challenges include microbial, chemical, personal and environmental hygiene. Historically, documented human tragedies and economic disasters due to consuming contaminated food occurred as a result of intentional or unintentional perso

An overview of mosquito vectors of Zika virus

The mosquito-borne arbovirus #Zika virus (ZIKV, Flavivirus, Flaviviridae), has caused an outbreak impressive by its magnitude and rapid spread. First detected in Uganda in Africa in 1947, from where it spread to Asia in the 1960s, it emerged in 2007 on the Yap Island in Micronesia and hit most islands in the Pacific region in 2013. Subsequently, #ZIKV was detected in the Caribbean, and Central and South America in 2015, and reached North America in 2016. Although ZIKV infecti

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