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Scientists develop new gene therapy strategy to delay aging

Researchers conducted genome-wide #CRISPR-based screens in premature aging stem cells & identified >100 candidate #senescence-promoting genes.

Among them, KAT7 (a histone acetyltransferase) was identified as a top target involved in cellular senescence.

#aging #longevity

Figure below: Gene therapy targeting Kat7 extends lifespan in naturally aged and progeria mice.

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