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MOSTLY MICROBES AND INFECTIOUS DISEASES

Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.

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mRNA vaccines changed the course of the pandemic. Now, they could cure all kinds of other diseases

#mRNA vaccines changed the course of the #COVID19 pandemic. Now, they are being developed to cure other diseases such as #AIDS, #cancer, #LymeDisease & #influenza. The COVID-19 pandemic is what historians refer to as an "inflection point," or a single event that has a dramatic and sweeping effect on the human story. In the case of this particular event, it changed the way we work, raised awareness about public health policy, contributed to the toppling of a president — and,

China Reports a Human Case of H5N6 Bird Flu

#China Reports a Human Case of #H5N6 Bird #Flu #avianflu #birdflu #influenza A man has been hospitalized in southwestern China after contracting the H5N6 strain of avian flu, Chinese state news media reported on Thursday, a reminder that the world is full of flu viruses even during a coronavirus pandemic. The man, 55, was hospitalized in Bazhong, a city in the southwestern province of Sichuan, after coming down with a fever and testing positive for the virus on July 6, the st

Case of Human Bird Flu Reported in China

Case of Human #BirdFlu Reported in #China #flu #avianflu #influenza A man in China has been hospitalized after contracting a strain of avian flu, a state broadcaster reported Thursday. The 55-year-old man tested positive for #H5N6, or avian influenza A, in Bazhong City, in China's southwestern Sichuan Province, the broadcaster said. The man began showing symptoms of a fever on June 30 and tested positive for the bird flu on July 6. Local authorities have activated an emergenc

How a Flu Virus Shut Down the Us Economy in 1872 - By Infecting Horses

The equine #influenza first appeared in horses near Toronto. Within days most animals in the city’s crowded stables caught the #flu virus. The US government tried to ban Canadian horses, but acted too late. In 1872 the U.S. economy was growing as the young nation industrialized and expanded westward. Then in the autumn, a sudden shock paralyzed social and economic life. It was an energy crisis of sorts, but not a shortage of fossil fuels. Rather, the cause was a virus that sp

The role of respiratory epithelium in host defense against influenza virus infection

#influenza #flu #infection The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialized structural cells and populations of resident immune cells come together to mount the first response to the virus, one which wo

Changes of avian influenza virus subtypes before and after vaccination in live poultry in China

#avianflu #flu #influenza #birdflu #China We investigated fluctuations in the detection rates of avian influenza virus (AIV) subtypes H5, H7, and H9 in live bird markets (LBMs) in Nanchang city, Chinese province Jiangxi, before and after the Chinese nationwide AIV vaccination campaign against highly pathogenic (HP) AIV subtype H5 and H7. Samples were tested for nucleic acid of type A avian influenza virus by real-time reverse transcription polymerase chain reaction technology

Some Pandemic Health Habits Deserve to Stay

#flu #influenza #masks #COVID19 #coronavirus #socialdistancing #handwashing In the West, we have learned that mask wearing is very helpful in stopping the spread of all kinds of respiratory illnesses; something people in many Asian countries have known for years. When the COVID pandemic finally retreats, the world will be different. We will have lost millions of lives—a tragic disaster that will devastate families and communities for decades to come. Other changes, of a less

The Pandemic Might Have Killed Off Some Flu Strains for Good

#flu #influenza #masks #publichealth #COVID19 #coronavirus #pandemic Scientists say that two common strains of the seasonal flu have seemingly vanished from circulation, likely due to public health measures like mask-wearing meant to slow the covid-19 pandemic. Though it will take time to confirm the disappearing act, the unexpected good news could make developing next season’s flu shot all the easier. Every year, various types of the flu spread across the world, usually foll

A man in China is found to have H10N3 bird flu, a reminder of a continued ‘concern for pandemic flu’

#flu #avianflu #birdflu #influenza #H10N3 A 41-year-old man in China’s eastern Jiangsu Province is the first known human to be infected with a strain of bird flu known as H10N3, China’s National Health Commission said on Tuesday — a development that experts said merited close monitoring because of an underlying continued risk of pandemic flus. Avian viruses do not typically spread among humans, but they can pose a danger to humans if they mix with a human virus, said Raina Ma

NIH launches clinical trial of universal influenza vaccine candidate

#flu #influenza #fluseason #fluvacccine #vaccines A first-in-human, Phase 1 trial assessing the safety and immunogenicity of an investigational nanoparticle influenza vaccine designed to provide long-lasting protection against multiple flu virus strains has begun at the National Institutes of Health Clinical Center in Bethesda, Maryland. Healthy participants 18 to 50 years old will receive either a licensed seasonal influenza vaccine or the experimental vaccine, FluMos-v1. Sc

China reports first human case of H10N3 bird flu

#H10N3 #flu #influenza #birdflu #avianflu A 41-year-old man in China's eastern province of Jiangsu has been confirmed as the first human case of infection with the H10N3 strain of bird flu, China's National Health Commission (NHC) said on Tuesday. The man, a resident of the city of Zhenjiang, was hospitalised on April 28 after developing a fever and other symptoms, the NHC said in a statement. He was diagnosed as having the H10N3 avian influenza virus on May 28, it said, but

China reports human case of H10N3 bird flu, a possible first

#H10N3 #flu #birdflu #avianflu #influenza A man in eastern China has contracted what might be the world’s first human case of the H10N3 strain of bird flu, but the risk of large-scale spread is low, the government said Tuesday. The 41-year-old man in Jiangsu province, northwest of Shanghai, was hospitalized April 28 and is in stable condition, the National Health Commission said on its website. No human case of H10N3 has been reported elsewhere, the commission said. “This inf

The role of respiratory epithelium in host defence against influenza virus infection

#flu #influenza #immunology #innateimmunity The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the vi

Emerging H5N8 avian influenza viruses

#flu #influenza #avianflu #birdflu Perspective article argues that #H5N8 avian flu represents a considerable public health concern, particularly considering the 1st human cases of H5N8 infection first reported last December. The first confirmed outbreak of highly pathogenic avian influenza virus (HPAIV) in birds was documented in Scotland in 1959 with the influenza A H5N1 subtype, although there have been numerous suspected HPAIV outbreaks documented globally since 1878. H5N1

Epigenetic reprogramming mechanisms of immunity during influenza A virus infection

#flu #influenza #immunity #immunology This paper reviews #epigenetic mechanisms by which influenza viruses affect cellular gene activity to control their life cycles, aiming to provide new insights into the complexity of functional interactions between viral and cellular factors, as well as to introduce novel targets for therapeutic intervention and vaccine development against influenza infections. Read more at: https://www.sciencedirect.com/science/article/pii/S1286457921000

Novavax combined influenza/COVID-19 vaccine shows promise in animal study

#COVID19 #coronavirus #flu #influenza Novavax Inc said its combined flu and COVID-19 vaccine produced functional antibodies against influenza and the coronavirus in a preclinical study. The company said the NanoFlu/NVX-CoV2373 vaccine elicited robust responses to both influenza A and B and protected against the SARS-CoV-2 virus. (https://refini.tv/3bg25TM) "Seasonal influenza and COVID-19 combination vaccines will likely be critical to combating emerging COVID-19 variants," s

Epigenetic reprogramming mechanisms of immunity during influenza A virus infection

#flu #epigenetics #immunology #influenza This paper reviews epigenetic mechanisms by which influenza viruses affect cellular gene activity to control their life cycles, aiming to provide new insights into the complexity of functional interactions between viral and cellular factors, as well as to introduce novel targets for therapeutic intervention and vaccine development against influenza infections. https://www.sciencedirect.com/science/article/pii/S1286457921000538

Epigenetic reprogramming mechanisms of immunity during influenza A virus infection

#flu #influenza #epigenetics This paper reviews #epigenetic mechanisms by which influenza viruses affect cellular gene activity to control their life cycles, aiming to provide new insights into the complexity of functional interactions between viral and cellular factors, as well as to introduce novel targets for therapeutic intervention and vaccine development against influenza infections. https://www.sciencedirect.com/science/article/pii/S1286457921000538

Epigenetic reprogramming mechanisms of immunity during influenza A virus infection

#influenza #flu #epigenetics This paper reviews epigenetic mechanisms by which influenza viruses affect cellular gene activity to control their life cycles, aiming to provide new insights into the complexity of functional interactions between viral and cellular factors, as well as to introduce novel targets for therapeutic intervention and vaccine development against influenza infections. https://www.sciencedirect.com/science/article/pii/S1286457921000538

Flu may play part in plaque-rupturing heart attacks

Getting a #flu vaccine can reduce the risk of a common type of #heart attack in people 60 and older, according to new research that suggests the #influenza virus plays a role in rupturing plaque. Researchers in Spain used data from five consecutive flu seasons and zeroed in on 8,240 people who had Type 1 heart attacks. They found flu and cold temperatures were each independently associated with an increased risk of that kind of heart attack, and flu shots could reduce that ri

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