Highlights Microbiota-driven inflammation and lipid uptake drive intestinal ILC3 lipotoxicity Inflammatory signaling suppresses fatty acid oxidation in ILC3s but not Th17 cells ILC3-specific immunometabolic vulnerability is conserved in intestine of mice and human HFD-mediated intestinal ILC3 depletion is reversible upon dietary normalization Summary Group 3 innate lymphoid cells (ILC3s) are key sensors of the intestinal environment, integrating dietary and microbial cues to maintain...

Highlights A global atlas and biogeography of human bacterial pathogens in soils are reported Dominant human bacterial pathogens are more abundant in wet ecosystems worldwide Soil biodiversity is negatively associated with the prevalence of human pathogens Many dominant pathogens are likely to increase their proportion in future climates Summary Soil-inhabiting pathogens threaten human health, but their biogeography and associations with soil biodiversity remain poorly understood. Here, we...

Highlights Bacteria were more abundant in coco coir, particularly in stationary clinostats Pseudomonadota  and  Actinomycetota  phyla were abundant under simulated gravity Biomarkers were highest in horizontal clinostats' coco coir under simulated gravity The GT2 and GT4 classes of glycosyl transferases were abundant in coco-coir samples The top four antibiotic resistance genes were  adeF, vanY, vanT , and  qacG ABSTRACT Kale is a member of the  Brassicaceae  family and contains a range of...