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Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.

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New study finds 6 ways to slow memory decline and lower dementia risk

A new study of more than 29,000 older adults has identified six habits — from eating a variety of foods to regularly reading or playing cards — that are linked with a lower risk of dementia and a slower rate of memory decline. #lifestyle #aging #longevity #dementia #diet #nutrition #exercise Eating a balanced diet, exercising the mind and body regularly, having regular contact with others, and not drinking or smoking — these six “healthy lifestyle factors” were associated wit

Fasting as key tone for COVID immunity

#SARSCoV2-induced #anorexia triggers systemic metabolic alterations. A new study shows that the ketone body β-hydroxybutyrate (BHB) improves COVID19 disease outcomes. Further, BHB metabolically and functionally reprograms CD4+ T cells, highlighting immunometabolic tuning of immunity in #COVID19. #Fasting #diet #nutrition #immunology Infection-induced anorexia is an evolutionarily conserved sickness behaviour that can mediate protective or detrimental immune functions1. Fastin

The obesity fighting mushroom: Chinese medicine counters diabetes and weight gain

#Reishi #microbiota #lingzhi #obesity #insulin #microbiome #Ganoderma #mushrooms #diet #nutrition As any gardener knows, plants need the right mix of fertilisers to flourish – and the same seems to be true for your gut bacteria. Microbiologist David Ojcius from Taiwan’s Chang Gung University and his colleagues found the secret to a healthy gut is what you feed them – and that perfect meal could come from a humble mushroom. They published their findings in Nature Communication

This mushroom might alter gut bacteria for the better, study finds

#microbiota #mushrooms #microbiome #diet #nutrition #obesity #diabetes #Reishi #lingzhi #insulin A #mushroom a day may keep the doctor away. The active ingredients in a Asian mushroom can change bacteria in your stomach for the better, researchers have found. By altering gut bacteria, the Reishi mushroom (Ganoderma lucidum) prevents and reverses symptoms of obesity in mice, including weight gain and insulin resistance. “Mice kept on a high-fat diet gained up to 25 percent

Intermittent fasting and why when you eat makes a difference

“Intermittent #fasting” may help ward off #obesity, as expected. More speculatively, there are signs in animal studies that the regimens might also enhance athletic endurance and cognition, alleviate diabetes and perhaps even help combat other medical conditions. #intermittentfasting #CR #diet #nutrition

Fiber-poor Western diets fuel inflammation

The transition of Sub-Saharan Africans from rural settings & traditional plant-rich diets to urban settings & calorie-dense Westernized diets has led to specific shifts in serum metabolites & activates a heightened proinflammatory state in immune cells. #inflammation #diet #nutrition

Food safety in the 21st century

Food is essential to life, hence #food #safety is a basic human right. Billons of people in the world are at risk of unsafe food. Many millions become sick while hundreds of thousand die yearly. The food chain starts from farm to fork/plate while challenges include microbial, chemical, personal and environmental hygiene. Historically, documented human tragedies and economic disasters due to consuming contaminated food occurred as a result of intentional or unintentional perso

Recent advances in the field of caloric restriction mimetics and anti-aging molecules

Caloric restriction (CR) mimetics are molecules that produce beneficial effects on health and longevity in model organisms and humans, without the challenges of maintaining a CR diet. Conventional CR mimetics such as metformin, rapamycin and spermidine activate autophagy, leading to recycling of cellular components and improvement of physiological function. We review here novel CR mimetics and anti-aging compounds, such as 4,4′-dimethoxychalcone, fungal polysaccharides, inorg

This mushroom might alter gut bacteria for the better, study finds

By altering the gut #microbiota, the #Reishi mushroom (#Ganoderma lucidum) prevents and reverses symptoms of #obesity in mice, including weight gain and insulin resistance. #diabetes #lingzhi #灵芝 #nutrition #diet #TCM #microbiome,weight%20gain%20and%20insulin%20resistance.&text=The%20ratio%20of%20two%20different,indicate%20gut%20health%2C%20Ojcius

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