Structural biology reveals new opportunities to combat tuberculosis
Researchers study the secretion system ESX-5 of Mycobacterium #tuberculosis at high resolution. The ESX-5 core is built of 30 protein units, which form a membrane pore to allow secretion of proteins that enable the bacteria to multiply inside human cells. Tuberculosis is one of the top ten causes of death worldwide, infecting about one-quarter of the world's population. Although it is treatable, the rise of multidrug-resistant tuberculosis poses a major threat to global healt