Highlights Teenagers (13–17 years) show the highest gut microbiota stability among healthy individuals aged 3–30 years. Core genera Faecalibacterium and Bifidobacterium have ICC > 0.90, highlighting their value as stable biomarkers for FMT donor screening. An ICC-based framework is proposed to enhance quantitative donor evaluation and standardize FMT practices. https://www.sciencedirect.com/science/article/pii/S2666517425001725

Highlights Over 6.5 million people face invasive fungal infections annually, with high mortality rates due to limited drug options, toxicity, costs, and increasing resistance. Current antifungal drugs primarily target the fungal cell membrane, DNA synthesis , or cell wall, limiting treatment efficacy and promoting resistance. New antifungal agents are in clinical trial stages with new mechanisms of action and/or improvements in the activity of the former. Drug repurposing

Hightlights The context summarizes the latest effects of rhizosphere microorganisms on plants. The context summarizes the mechanisms by which plant hosts shape their own rhizosphere microbial communities . Further explore its impact and utilization potential on microbial communities from the aspects of genotype, functional genes. Provide new ideas for the development of green fertilizer, green agriculture and environmental restoration. https://www.sciencedirect.com/science/

Highlights Isolation and characterization of drought-tolerant PGPR strains from the rhizosphere of cactus plant. Bacillus strains were observed to be highly drought-tolerant with PGP characteristics. Bacterial strains work as bio-inoculants to improve crop resilience and production in water-stressed environments. https://www.sciencedirect.com/science/article/pii/S2666517424001020

Highlights Impact of biofertilizers on soil microbial diversity and functionality. Role of microbial-based bio-inoculum in improving plant growth and soil health. Growth-promoting attributes of biofertilizer and its effectiveness over inorganic fertilizers for sustainable agriculture . Prospects of commercialization, bioeconomy and production of biofertilizers for the development of agricultural productivity and socioeconomic status. https://www.sciencedirect.com/science/ar

Highlights Chemical pesticides pose serious risks to human health and environmental sustainability, especially in soil and aquatic systems. Microbial communities, including bacteria, fungi, and algae, offer promising, eco-friendly solutions for pesticide degradation and detoxification. OMICs technologies unravel microbial metabolic networks, enabling the discovery of key organisms and molecular components involved in pesticide breakdown. Emerging tools like gene editing and A

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L'interdiction des antibiotiques favorisant la croissance (PCA) dans les régimes à base de produits laitiers en 2006 était principalement motivée par les inquiétudes des producteurs laitiers concernant la résistance aux antibiotiques, qui constitue une menace pour la santé humaine et animale. L’utilisation générale d’antibiotiques en agriculture conduit au développement de cultures bactériennes résistantes, réduisant leur efficacité dans le traitement des infections. Par aill

Wherever you happen to be reading this, if you look around, you will likely see many objects made of plastic. University of the Pacific is contributing to a global discussion about this ubiquitous material and its impact on the environment through its involvement with the Veolia Institute’s latest publication, Reinventing Plastics , part of its FACTS Reports series.  The idea for this issue came from Dr. David Ojcius, department chair and professor in the Biomedical Sciences

Inflammasomes are cytosolic multiprotein complexes of the innate immune system responsible for the activation of inflammatory responses and cell death . [1] [2] They are formed as a result of specific cytosolic pattern recognition receptors (PRRs), which are molecular sensors of microbe-derived pathogen-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs) from the host cell, or homeostatic disruptions. [1] [2] [3] Activation and assemb

The human microbiome is the aggregate of all microbiota that reside on or within human tissues and biofluids along with the corresponding anatomical sites in which they reside, [1] [2] including the gastrointestinal tract , skin , mammary glands , seminal fluid , uterus , ovarian follicles , lung , saliva , oral mucosa , ocular surface , and the biliary tract . Types of human microbiota include bacteria , archaea , fungi , protists , and viruses . Though micro-animals

Life extension  is the concept of extending the human  lifespan , either modestly through improvements in medicine or dramatically by increasing the  maximum lifespan  beyond its generally-settled biological limit of  around 125 years . [1]  Several researchers in the area, along with "life extensionists", " immortalists ", or " longevists " (those who wish to achieve longer lives themselves), postulate that future breakthroughs in tissue  rejuvenation ,  stem cells ,  regene

This commentary describes the changes taking place in dentistry and speculates on improvements that could happen soon. Advances in health care will have an impact on the integration and delivery of oral care; conversely, there is growing acceptance that oral health impacts systemic health. Technological innovations are changing the face of medical care and are quickly becoming integrated into dentistry. Advances in novel antimicrobials, genomics, robotics and artificial intel

The immune system employs a temporal hierarchy of effector mechanisms to combat infections by intracellular pathogens. The nonspecific response is independent of MHC and can be activated rapidly, while the specific response is slower, more specific, and requires major histocompatibility complex (MHC) molecules. MHC-dependent responses have been characterized extensively  in vitro  for antigens presented by polymorphic MHC class la and class II proteins and recognized by T lym

Boswellia  trees, found throughout the Middle East and parts of Africa and Asia, are the source of frankincense oil. Since antiquity, frankincense has been traded as a precious commodity, but it has also been used for the treatment of chronic disease, inflammation, oral health, and microbial infection. More recently, the bioactive components of  Boswellia  trees have been identified and characterized for their effects on cancer, microbial infection (especially infection by or

The  history of dental treatments  dates back to thousands of years. [1] [2]  The scope of this article is limited to the pre-1981  history . The earliest known example of  dental caries  manipulation is found in a  Paleolithic  man, dated between 14,160 and 13,820  BP . [3]  The earliest known use of a  filling  after removal of decayed or infected  pulp  is found in a Paleolithic who lived near modern-day  Tuscany , Italy, from 13,000 to 12,740 BP. [4]  Although inconclusiv

La  boca , también denominada como una  cavidad bucal  o  cavidad oral,  siendo en realidad divisiones en sí de la boca del aparato digestivo; [1] ​ es la abertura corporal por la que se ingieren  alimentos . [2] ​ Está ubicada en la  cara  y constituye en su mayor parte el  aparato estomatognático , así como la primera parte del  aparato digestivo . La boca se abre a un espacio previo a la  faringe  llamado cavidad oral, o cavidad bucal. La boca  humana  está cubierta por lo

Dean Prof. Dr. Zahid Yousaf of the University of Gujrat (UOG) embarked on a significant visit to the University of the Pacific,...

Highlights • Exercise-induced microbial formate enhances immune checkpoint inhibitor efficacy • Microbiota-derived formate is essential...

Frankincense oil, originating from Boswellia trees in the Middle East, Africa, and parts of Asia, has a rich history as a valuable remedy...