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MOSTLY MICROBES AND INFECTIOUS DISEASES

Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.

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New study finds 6 ways to slow memory decline and lower dementia risk

A new study of more than 29,000 older adults has identified six habits — from eating a variety of foods to regularly reading or playing cards — that are linked with a lower risk of dementia and a slower rate of memory decline. #lifestyle #aging #longevity #dementia #diet #nutrition #exercise Eating a balanced diet, exercising the mind and body regularly, having regular contact with others, and not drinking or smoking — these six “healthy lifestyle factors” were associated wit

A Drug to Treat Aging May Not Be a Pipe Dream

New approaches to the biology of #senescence can make lives longer and healthier. #aging #senolytics LIFE EXPECTANCY IN the best-performing countries has been increasing by three months per year every year since the early 1800s. Throughout most of human history, you had a roughly 50–50 chance of making it into your twenties, mainly due to deaths from infectious diseases and accidents. Thanks to medical advances, we’ve gradually found ways to avoid and treat such causes of dea

Your microbiome ages as you do—and that’s a problem

Study found that gut #microbiome changes with age, & that it loses aspects of a general core microbiome & strays toward a more individual one. But this isn’t necessarily a good thing. This uniqueness seems to be linked to unhealthy #aging. We’re all crawling with bugs. Our bodies are home to plenty of distinct ecosystems that are home to microbes, fungi, and other organisms. They are crucial to our well-being. Shifts in the microbiome have been linked to a whole host of disea

Anti-insulin protein linked to longevity and reproduction in ants

In many animals, having many offspring is linked to a shorter #lifespan. A study shows that queen ants exhibit high metabolism for reproduction without undergoing #aging by generating an anti-insulin protein that blocks only part of the #insulin pathway. An insulin-suppressing protein may be the fountain of youth for ants and provides clues about aging in other species, according to a study led by New York University researchers. Published in Science, the study shows that que

How stress may accelerate aging of the immune system

Stress & #aging of the immune system. As people age, their immune systems naturally begin to decline. But not all immune systems age at the same rate. A recent study found that social stress is associated with signs of accelerated #immunosenescence. As people age, their immune systems naturally begin to decline. This aging of the immune system, called immunosenescence, may be an important part of age-related health problems such as cancer and cardiovascular disease, as well

Live Fast, Die Young? Or Live Cold, Die Old?

Researchers have found that body temperature exerts a greater effect on #lifespan than metabolic rate. #aging #metabolism Researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences, along with collaborators from Wenzhou University and the University of Aberdeen, have found that body temperature exerts a greater effect on lifespan than metabolic rate. In this study, the researchers utilized an unusual situation where metabolic rate

Covid Cases Linked to Brain Shrinkage, Cognitive Decline Months Later

Even a mild case of #COVID19 can damage the brain, leading to shrinkage equivalent to up to a decade of #aging, according to a new study. The findings represent more evidence of the #SARSCoV2 #coronavirus' impact on the central nervous system. Read more at: https://www.bloomberg.com/news/articles/2022-03-07/brain-shrinkage-cognitive-decline-found-months-after-mild-covid?cmpid=BBD031222_WKND&utm_medium=email&utm_source=newsletter&utm_term=220312&utm_campaign=weekendreading

Immunology Research Professor David Ojcius Explains the Effects of Aging on Our Immune System

If you feel like you’re slowing down a bit as you age, you’re not alone. Many of our systems (including our brain) tend to taper off as we get older and the immune system is no exception, says David Ojcius, an expert in #immunology research at the University of the Pacific in San Francisco, California. #aging Read more at: https://davidojcius.com/immunology-research-professor-david-ojcius-explains-the-effects-of-aging-on-our-immune-system/

A metabolome atlas of the aging mouse brain.

Study finds almost all metabolites differ between brain regions or age groups, but not by sex. A shift in sphingolipid patterns during #aging is accompanied by large changes in other #metabolic pathways. Abstract: The mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of the brain metabolome and its changes during diseases or aging remain poorly understood. Here, we generate a metabolome atlas of the aging wildtype mouse brain from 10 anato

Gut Bacteria Change as You Get Older—and May Accelerate Aging

A study finds that #aging is associated with #microbiome changes, & that these alterations are distinct from those connected to diseases or medication use. The body’s constellation of gut bacteria has been linked with various aging-associated illnesses, including cardiovascular disease and type 2 diabetes. Now a study has found that aging itself is associated with microbiome changes, and that these alterations are distinct from those connected to diseases or medication use. T

Age and aging have critical effects on the gut microbiome

Researchers have found that #aging produces significant changes in the #microbiome of the human small intestine distinct from those caused by medications or illness burden. Researchers at Cedars-Sinai have found that aging produces significant changes in the microbiome of the human small intestine distinct from those caused by medications or illness burden. The findings have been published in the journal Cell Reports. "By teasing out the microbial changes that occur in the sm

Regular Exercise May Keep Your Body 30 Years ‘Younger’

The muscles of older men & women who have exercised for decades are indistinguishable in many ways from those of healthy 25-year-olds, according to a new study of active septuagenarians. #exercise #aging #longevity These men and women also had much higher aerobic capacities than most people their age, the study showed, making them biologically about 30 years younger than their chronological ages, the study’s authors concluded. All of us are aging every second, of course, whic

The Longest-Living People in the World Eat These 4 Anti-Inflammatory Spices Every Day

The Longest-Living People in the World Eat These 4 Anti-Inflammatory Spices Every Day #inflammation #aging #longevity #turmeric #blackpepper #garlic #ginger The five Blue Zones regions are known for being home to the longest-living people in the world. In these areas, people not only regularly live into the triple digits, but their brains and bodies are both still functioning well. There are many lifestyle factors that Blue Zones founder, Dan Buettner, has found are shared by

New Research Discovers Potential of Gut Microbes To Reverse Aging in the Brain

New study shows that it's possible to reverse aspects of #aging-related deterioration in the #brain and cognitive function via the the gut #microbiota from young mice Research from APC Microbiome Ireland (APC) at University College Cork (UCC) published on August 9, 2021, in the leading international scientific journal Nature Aging introduces a novel approach to reverse aspects of aging-related deterioration in the brain and cognitive function via the microbes in the gut. As o

Centenarians have a distinct microbiome that may help support longevity

A study found that centenarians, compared to younger people, have higher levels of several bacterial species that produce secondary bile acids, which are thought to help protect the intestines from pathogens & regulate the body's immune responses. #microbiome #microbiota #aging Centenarians are less susceptible to age-related chronic diseases and more likely to survive infectious diseases. Now, a new study reveals that people who live to be 100 or older have a unique microbio

‘Inflammation clock’ can reveal body’s biological age

Using machine learning, researchers create an ‘inflammatory clock of aging’ (iAGE) that shows the biological age of our immune system. #aging #inflammation A new type of age ‘clock’ can assess chronic inflammation to predict whether someone is at risk of developing age-related disorders such as cardiovascular and neurodegenerative disease. The clock measures ‘biological age’, which takes health into consideration and can be higher or lower than a person’s chronological age. T

First actionable clock that predicts immunological health and chronic diseases of aging

Researchers from the Buck Institute and Stanford University have created an inflammatory clock of aging (iAge) which measures inflammatory load and predicts multi-morbidity, frailty, immune health, cardiovascular #aging and is also associated with exceptional longevity in centenarians. Utilizing deep learning, a form of #AI, in studies of the blood immunome of 1001 people, researchers also identified a modifiable chemokine associated with cardiac aging which can be used for e

First actionable clock that predicts immunological health and chronic diseases of aging

Researchers from the Buck Institute and Stanford University have created an inflammatory clock of #aging (iAge) which measures inflammatory load and predicts multi-morbidity, frailty, immune health, cardiovascular aging and is also associated with exceptional longevity in centenarians. Utilizing deep learning, a form of AI, in studies of the blood immunome of 1001 people, researchers also identified a modifiable chemokine associated with cardiac aging which can be used for ea

With age, insufficient tryptophan alters gut microbiota, increases inflammation

With #aging, a diet lacking in the essential amino acid #tryptophan -- which has a key role in our mood, energy level and immune response -- makes the gut #microbiome less protective and increases #inflammation body-wide, investigators report. In a normally reciprocal relationship that appears to go awry with age, sufficient tryptophan, which we consume in foods like milk, turkey, chicken and oats, helps keep our #microbiota healthy. A healthy microbiota in turn helps ensure

Three years younger in just eight weeks? A new study suggests yes!

#aging #epigenetic #lifestyle #longevity A clinical trial shows one can reduce biological age (as measured by the Horvath 2013 DNAmAge clock) by >3 years in only 8 weeks with diet & lifestyle through balancing DNA methylation. A groundbreaking clinical trial shows we can reduce biological age (as measured by the Horvath 2013 DNAmAge clock) by more than three years in only eight weeks with diet and lifestyle through balancing DNA methylation. A first-of-its-kind, peer-reviewed

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