top of page
Search
Writer's pictureDavid Ojcius

Metformin decelerates aging clock in male monkeys

Highlights

#Metformin prevents brain atrophy, elevating cognitive function in aged male primates

• Metformin slows the pace of #aging across diverse male primate tissues

• Metformin counterparts neuronal aging, delivering geroprotection via Nrf2 in male primates


Summary


In a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The study encompassed a comprehensive suite of physiological, imaging, histological, and molecular evaluations, substantiating metformin’s influence on delaying age-related phenotypes at the organismal level. Specifically, we leveraged pan-tissue transcriptomics, DNA methylomics, plasma proteomics, and metabolomics to develop innovative monkey aging clocks and applied these to gauge metformin’s effects on aging. The results highlighted a significant slowing of aging indicators, notably a roughly 6-year regression in brain aging. Metformin exerts a substantial neuroprotective effect, preserving brain structure and enhancing cognitive ability. The geroprotective effects on primate neurons were partially mediated by the activation of Nrf2, a transcription factor with anti-oxidative capabilities. Our research pioneers the systemic reduction of multi-dimensional biological age in primates through metformin, paving the way for advancing pharmaceutical strategies against human aging.


Read full article at:



13 views0 comments

Comments


Post: Blog2_Post
bottom of page