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MOSTLY MICROBES AND INFECTIOUS DISEASES

Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.

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How our microbiome is shaped by family, friends and even neighbors

People living in same household or in regular contact tend to have same microbes in their guts & mouths. The study raises possibility that diseases linked to #microbiome dysfunction, including #cancer, #diabetes & #obesity, could be partly transmissible. People living in the same household share more than just a roof (and pints of milk). Be they family or flatmate, housemates tend to have the same microbes colonizing their bodies, and the longer the cohabitation, the more sim

David Ojcius Discusses The Association Between Oral Health And Systemic Disease

The association between #oralhealth and systemic disease has been established for some time. Medical research has pointed to a link between health conditions such as #diabetes and #cardiovascular disease and #periodontal disease. What’s still debatable though is how #oral bacteria can have such an impact on the oral cavity that it could lead to health conditions in other parts of the body. David Ojcius is the assistant dean of research and the chair of the Biomedical Sciences

Oral and gut microbes can inactivate an antidiabetic drug

Researchers discovered that the oral & gut #microbiome can inactivate the antidiabetic drug #acarbose, which may affect the drug's efficacy in some #diabetes patients. A microbiome-encoded enzyme, called Mak1, modifies acarbose, causing its inactivation. Acarbose is a commonly prescribed antidiabetic drug that helps control blood sugar levels by inhibiting human enzymes that break down complex carbohydrates. Now, new research from the laboratory of Princeton researcher Mohame

The Health Toll of Poor Sleep

#sleep deprivation increases the risk of developing #heart disease, #cancer, #dementia, high blood pressure, stroke & Type 2 #diabetes. It muddies clear thinking, depletes energy, increases irritability & dampens one’s sex drive. Sleep — both its quantity and its quality — is one of the most frequently discussed health topics. How often have you told a friend or relative, “I’m exhausted, I was up half the night”? Surveys have found that more than a third of American adults ar

Dentistry is converging with medicine

Although they have been separate professions, dentistry is now converging with medicine. There is growing awareness that #oral health affects systemic health. Dentists are in a good position to diagnose early signs of non-oral diseases, such as #diabetes and #heart disease. Read more at: https://ideamensch.com/david-ojcius/

This mushroom might alter gut bacteria for the better, study finds

This mushroom might alter gut bacteria for the better, study finds. #Ganoderma #Reishi #Lingzhi #obesity #diabetes #insulin #microbiota #microbiome #芝草 A mushroom a day may keep the doctor away. The active ingredients in a Asian mushroom can change bacteria in your stomach for the better, researchers have found. By altering gut bacteria, the Reishi mushroom (Ganoderma lucidum) prevents and reverses symptoms of obesity in mice, including weight gain and insulin resistance. “Mi

Inflammasome activation at the crux of severe COVID-19

Review of evidence that #SARSCoV2#coronavirus directly or indirectly activates #inflammasomes, leading to secretion of IL-1 family cytokines (IL-1beta and IL-18), and pyroptosis, an inflammatory form of cell death. The #COVID19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly people and those with co-morbidities such as #obesity and #diabetes. Severe disease is c

Babies at risk for diabetes may have microbiota restored

Newborns at risk for Type 1 #diabetes because they were given antibiotics may have their gut microorganisms restored with a maternal fecal transplant, according to a new study. #microbiota #microbiome The study, which involved genetic analysis of mice, appears in the journal Cell Host & Microbe. The findings suggest that newborns at risk for Type 1 diabetes because their microbiome—the trillions of beneficial microorganisms in and on our bodies—were disturbed can have the con

Scientists link genetic makeup of bacteria in the human gut to human diseases

The findings link sets of bacterial genes to the presence of coronary artery disease, #cirrhosis of the liver, inflammatory bowel disease #IBD, #colon cancer & type 2 #diabetes. Analyzing the genetic makeup of bacteria in the human gut, the team has successfully linked groups of bacterial genes, or "genetic signatures," to multiple diseases. The work brings scientists closer to developing tests that could predict disease risk or identify disease presence based on a sampling o

This mushroom might alter gut bacteria for the better, study finds

#microbiota #mushrooms #microbiome #diet #nutrition #obesity #diabetes #Reishi #lingzhi #insulin A #mushroom a day may keep the doctor away. The active ingredients in a Asian mushroom can change bacteria in your stomach for the better, researchers have found. By altering gut bacteria, the Reishi mushroom (Ganoderma lucidum) prevents and reverses symptoms of obesity in mice, including weight gain and insulin resistance. “Mice kept on a high-fat diet gained up to 25 percent

Association between periodontal pathogens and systemic disease

#oralhealth #inflammation #Alzheimers #pregnancy #pneumonia #obesity #diabetes #heartidisease A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-produ

Genetic admixture in the South Pacific: From Denisovans to the human immune response

#immunology #evolution Scientists have looked at understudied human populations from the South Pacific, which are severely affected by a variety of diseases, including vector-borne infectious diseases such as #Zika virus, #dengue, and #chikungunya, and metabolic diseases such as #obesity and #diabetes. Using genome sequencing of 320 individuals, the scientists have investigated how human populations have biologically adapted to the environments of the Pacific islands and how

Association between periodontal pathogens and systemic disease

#Alzheimers #microbiota #microbiome #oralhealth #dental #dentistry #oral #heart A growing body of literature suggests that there is a link between #periodontitis and systemic diseases. These diseases include #cardiovascular disease, gastrointestinal and #colorectal cancer, #diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of #periodontal pathogens and their metabolic by-products in th

This mushroom might alter gut bacteria for the better, study finds

A #mushroom a day may keep the doctor away. The active ingredients in a Asian mushroom can change bacteria in your stomach for the better, researchers have found. By altering gut bacteria, the #Reishi mushroom (Ganoderma lucidum) prevents and reverses symptoms of #obesity in mice, including weight gain and insulin resistance. #microbiota #microbiome #diabetes https://www.pbs.org/newshour/science/reishi-mushroom-can-alter-gut-bacteria-better

Association between periodontal pathogens and systemic disease

A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-products in the mouth may in fact modulate the immune response beyond the oral cavity, thus promoti

The Association Between Oral Health And Systemic Disease

Oral health has been linked to systemic diseases in patients who suffer from diabetes, pulmonary disease, & in pregnant women. Improving oral health could have a direct impact on the general health of the individual & prevent other diseases as well. #oralhealth #diabetes #heart #pregnancy #microbiology #inflammation https://www.trueactivist.com/david-ojcius-discusses-the-association-between-oral-health-and-systemic-disease/

As you grow older, some preventive medical tests can be skipped

#aging patients still should have an annual “wellness” visit to check blood pressure, blood sugar (for the presence of Type 2 #diabetes), cholesterol, bone density (for #osteoporosis), #obesity and underweight (for frailty), skin (for cancerous lesions), #hearing, #vision and balance (to evaluate the risk of falls), and cognition. They also should keep up with certain #vaccinations, such as flu, shingles, tetanus and pneumonia. But they might be able to avoid certain tests if

Researchers identify bacteria that promote metabolic and mental health

Researchers identified Bifidobacterium longum APC1472 as regulator of appetite & metabolism. In overweight or obese people, the novel bacterial strain reduced fasting blood glucose levels & normalize levels of both ghrelin & the stress hormone cortisol. #microbiology #obesity #stress #diabetes https://medicalxpress.com/news/2020-12-bacteria-metabolic-mental-health.html

This mushroom might alter gut bacteria for the better, study finds

By altering the gut #microbiota, the #Reishi mushroom (#Ganoderma lucidum) prevents and reverses symptoms of #obesity in mice, including weight gain and insulin resistance. #diabetes #lingzhi #灵芝 #nutrition #diet #TCM #microbiome https://www.pbs.org/newshour/science/reishi-mushroom-can-alter-gut-bacteria-better#:~:text=By%20altering%20gut%20bacteria%2C%20the,weight%20gain%20and%20insulin%20resistance.&text=The%20ratio%20of%20two%20different,indicate%20gut%20health%2C%20Ojcius

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