Negative Regulatory NLRs Mitigate Inflammation via NF-κB Pathway in Inflammatory Bowel Disease
A subset of NLRs function to mitigate overzealous pro-inflammatory signaling produced by NF-κB activation. Under normal pathophysiologic...
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MOSTLY MICROBES AND INFECTIOUS DISEASES
Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.
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Fasting as key tone for COVID immunity
#SARSCoV2-induced #anorexia triggers systemic metabolic alterations. A new study shows that the ketone body β-hydroxybutyrate (BHB)...
How your body clock drives your immune system
The body's internal clock affects the immune system in ways scientists in the burgeoning field of #circadian #immunology are beginning to...
What triggers severe COVID? Infected immune cells hold clues
Two studies show that immune cells infected with #SARSCoV2 can stimulate a large inflammatory response via #inflammasome activation. In...
Current Research in Microbial Sciences - Editorial Board
Co-editors-in-chief Miranda Hart and David Ojcius #openaccess #microbiology #immunology #microbes #environment Find entire editorial...
How the Immune System Senses Danger: Immunology Researcher David Ojcius Explains
It’s no secret that we rely on our immune systems to fight off common infections. But what you might not know is that the immune system...
Immunology Research Professor David Ojcius Explains the Effects of Aging on Our Immune System
If you feel like you’re slowing down a bit as you age, you’re not alone. Many of our systems (including our brain) tend to taper off as...
David Ojcius -- on Lifelong Learning as a Researcher
#microbiology #LifelongLearning #education #research #biophysics #Pacific #immunology Interview at Thrive Global What do you love most...
The role of endocytic trafficking in antigen T cell receptor activation
This review article summarizes the molecular mechanisms of T cell receptor (TCR) #endocytosis and recycling, both in steady state and...
The Moderna vaccine makes more antibodies than Pfizer's. Does it matter?
#coronavirus #SARSCoV2 #immunity #immunology #COVID19 The Moderna vaccine makes more antibodies than Pfizer's. Does it matter? Antibodies...
Prior exposure to common cold coronaviruses enhances immune response to SARS-CoV-2
Researchers show that cross-reactive CD4+ T cells found in people previously exposed to common cold coronaviruses enhance the body's...
Scaling the tips of the ALPS
by Frédéric Rieux-Laucat, Jean M. Kanellopoulos, David M. Ojcius #apoptosis #immunology #FAS #autoimmunity This special issue contains...
Human Blood Harbors Cell-Free Microbial DNA
After controlling for high levels of bacterial contamination in their lab and reagents, researchers detect microbial genetic material in...
New impact factor for Biomedical Journal is now 4.91 !!
The new (2020) #impactfactor for Biomedical Journal is 4.91. The journal continues to improve. We thank all authors and editors for your...
Purinergic signaling: a new front-line determinant of resistance and susceptibility in leishmaniasis
#immunology #innateimmunity #Leishmania Leishmaniasis is a neglected tropical disease that causes several clinical manifestations....
The genetic landscape of the FAS pathway deficiencies
#genetics #autoimmunedisease #autoimmunity #immunology #apoptosis Dysfunction of the FAS-FASLG pathway causes a lymphoproliferative...
Cause or effect? The spatial organization of pathogens and the gut microbiota in disease
#microbiota #microbiome #immunology #microbiology The human gut hosts a dense and diverse microbial community, spatially organized by...
Multivalent antibodies show high potency against SARS-CoV-2 in new study
#SARSCoV2 #antibodies #immunology #coronavirus #COVID19 Since the beginning of the severe acute respiratory syndrome coronavirus 2...
Special Issue Call for Papers: Advances in Microbial Pathogenesis
#microbiology #pathogenesis #immunology #immunity #bacteria #virus #virology #mycology #infectiousdisease #genetics #microbiota The...
Luring bacteria into an evolutionary trap to reduce treatment resistance
#immunology #Salmonella #vaccines #evolution #microbiology Researchers succeeded in developing an oral vaccine against Salmonella that...
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