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MOSTLY MICROBES AND INFECTIOUS DISEASES

Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.

Bacteria, Bacterial colony, Microbes, Sa
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Inhibiting glutaminolysis in mice found to eliminate senescent cells

Researchers found that inhibiting kidney-type glutaminase-dependent glutaminolysis in mice can lead to elimination of #senescent cells. Senescent cells play a role in development of #aging-related diseases such as arteriosclerosis & muscle degeneration. https://medicalxpress.com/news/2021-01-inhibiting-kga-dependent-glutaminolysis-mice-senescent.html

Targeting metabolism to influence aging

Glutamine has a host of metabolic functions, including biosynthesis, redox maintenance, and chromatin biology. Drugs are currently available to target glutamine and related metabolism. However, the use of these compounds has been limited by finding appropriate applications because the role of #glutamine in health and disease is still poorly understood. Some studies have pointed to a limited role of glutamine #metabolism in vivo; others have found specific roles in critical ar

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