Targeting metabolism to influence aging
Glutamine has a host of metabolic functions, including biosynthesis, redox maintenance, and chromatin biology. Drugs are currently available to target glutamine and related metabolism. However, the use of these compounds has been limited by finding appropriate applications because the role of #glutamine in health and disease is still poorly understood. Some studies have pointed to a limited role of glutamine #metabolism in vivo; others have found specific roles in critical areas of biomedical interest, such as the potentiation of immune responses in cancer.
A new study reports a role for glutamine in maintaining the viability of #senescent cells and the #senescence-associated secretory phenotype, which may be a major factor in the #aging process. Thus, targeting glutamine and associated metabolic processes could be an attractive, clinically feasible way to modify the aging process.