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MOSTLY MICROBES AND INFECTIOUS DISEASES
Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.

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Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus
• #Staphylococcus aureus activates #NLRP3 #inflammasome in macrophages • NLRP3 activation --> depletion of glucose in macrophage...
David Ojcius
Sep 16, 20231 min read


The oral microbiome: diversity, biogeography and human health
Review article highlights recent understanding of biogeography of oral niches at the species level & summarizes the relationship between...
David Ojcius
Sep 12, 20233 min read
More reasons to eat mushrooms & fried crickets!
Study in mice found that digesting #chitin, an abundant dietary fiber in insect exoskeletons & mushrooms & crustacean shells, engages the...
David Ojcius
Sep 9, 20232 min read


A GWAS in the pandemic epicenter highlights severe COVID-19 risk locus introgressed by Neanderthals
Large GWAS indicated that genetic factors influence the response to #SARSCoV2. However, sex, age, concomitant diseases, differences in...
David Ojcius
Sep 3, 20231 min read


How a simple mouth rinse may be able to predict heart disease risk
Study shows that a simple mouth rinse that checks white blood cell levels may be helpful in predicting #heart disease. The rinse can...
David Ojcius
Aug 20, 20232 min read


Chlamydia and apoptosis: life and death decisions of an intracellular pathogen
The chlamydiae are important obligate intracellular prokaryotic pathogens that, each year, are responsible for millions of human...
David Ojcius
Aug 14, 20232 min read


Cigarette smoking exposure disrupts the regenerative potential of dental pulp stem cells
Introduction: #Smoking is known to alter the regenerative and immunomodulatory properties of many types of mesenchymal stem cells (MSCs)....
David Ojcius
Aug 4, 20233 min read


”We’re All Asgardians”: Scientists Discover New Clues About the Origin of Complex Life
According to newest study, all complex life forms (eukaryotes) trace their roots back to a common ancestor among a group of microbes...
David Ojcius
Aug 2, 20232 min read


Weaker immune response in children with mitochondrial disorders
Researchers find that altered B cell function in children with mitochondrial disorders leads to a weaker & less diverse antibody response...
David Ojcius
Jul 8, 20231 min read


Senolytics combat COVID-19 in aging
#aging increases vulnerability to respiratory viral infections, including by #SARSCoV2. Delval et al. established a causal role for...
David Ojcius
Jul 7, 20234 min read


Parabacteroides distasonis uses dietary inulin to suppress NASH via pentadecanoic acid
Study shows that gut #microbiota members can use dietary fibre to generate beneficial metabolites to suppress metabolic disease....
David Ojcius
Jun 30, 20231 min read


Pacific has one of most successful years for grants in school history
University of the Pacific secured 62 grants from federal, state and county agencies totaling more than $36 million—one of the best years...
David Ojcius
Jun 26, 20233 min read


Hunter-gatherer lifestyle fosters thriving gut microbiome
Sequencing the #microbiome of hunter-gatherers & city-dwellers shows that Western lifestyle decreases diversity of gut-bacteria...
David Ojcius
Jun 24, 20233 min read


Researchers uncover a cellular process that leads to inflammation
Cedars-Sinai investigators have identified several steps in a cellular process responsible for triggering one of the body's important...
David Ojcius
Jun 18, 20233 min read


Negative Regulatory NLRs Mitigate Inflammation via NF-κB Pathway in Inflammatory Bowel Disease
A subset of NLRs function to mitigate overzealous pro-inflammatory signaling produced by NF-κB activation. Under normal pathophysiologic...
David Ojcius
Jun 14, 20234 min read


Taurine deficiency as a driver of aging
Studying various animals, a study found that the amount of the semi-essential amino acid #taurine in circulation decreased with age....
David Ojcius
Jun 8, 20233 min read


Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes
Gut #microbiota influence host immunity and metabolism during obesity. Bacterial sensors of the innate immune system relay signals from...
David Ojcius
Jun 3, 20237 min read


In China (and elsewhere), an Unseen & Dangerous Foe Takes Root: Lethal Fungi.
Rising temperatures & ecosystem disturbances are creating a hotbed for fungi that can spark hard-to-treat infections in peoples’ lungs,...
David Ojcius
May 28, 20234 min read


Oral Microbiome and Health
Guest editors: Ozlem Yilmaz and David Ojcius. There is growing awareness that microbes in the oral cavity have a large effect on both...
David Ojcius
May 25, 20231 min read


Centenarians have diverse gut virome w/ potential to modulate metabolism & promote healthy lifespan
Compared with viromes of young adults (>18 yr) & old people (>60 yr), centenarians have diverse #virome including previously undescribed...
David Ojcius
May 15, 20231 min read
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