Microbial fuel cell (MFC) that generates bioelectricity from biodegradable waste receives significant interest to biologists. Fungi plays a significant role as both anodic and cathodic catalysts in MFCs. Saccharomyces cerevisiae is a fungus species with characteristics for the transfer of electrons through mediators such as methylene blue (MB), neutral red (NR) or without a mediator. Significant performance of fungal cells in exocellular electron transfer (EET), their interactions with the electrode and the use of yeast cell-based MFCs in wastewater treatment are promising. The present article highlighted the physico-chemical factors affecting the performance of fungal-mediated MFCs in terms of power output and degradation of organic pollutants, along with the challenges associated with fungal MFCs. In addition to this comparative assessment of the fungal-mediated bio-electrochemical system, their exciting development, possible application and a number of challenges were discussed.
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