Mouth‑to‑Gut Microbial Transmission Enables Accurate, Non‑Invasive GI Cancer Detection

Paired oral–fecal microbiomes from 507 individuals revealed elevated mouth‑to‑gut bacterial transmission in gastrointestinal cancers. A mouth‑to‑feces index captured disease‑specific signatures and powered a classifier that outperformed fecal occult blood testing, enabling sensitive, non‑invasive detection across multiple cohorts.

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https://www.sciencedirect.com/science/article/pii/S1931312826003082