Inflammasomes play a major role in the immune response to infection, development of #autoimmune disease, and control of #cancer. Western blots were originally used in the early 2000s to characterize #inflammasome activation. Since then, a panoply of techniques has been developed to characterize and visualize inflammasome activation in cells, tissues, and animals. This review article describes the most common techniques used by researchers in the inflammasome field and proposes that cell-specific characterization of inflammasome activation in tissues or animals may soon be commonly reported.
Introduction
The inflammasome has emerged in recent years as a pivotal regulator of immune homeostasis and disease pathogenesis. By understanding the intricate mechanisms governing inflammasome activation and regulation, we can uncover novel therapeutic targets for treating inflammatory disorders, infectious diseases, and cancer. Application of accurate methodology and modern tools play a critical role in the study of the inflammasome, elucidating its role in modulating innate immunity, inflammation, and disease progression. This article will review some traditional and recent methods in research on the inflammasome.
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