Highlights CBASS antagonizes phage replication while preserving cell viability in P. aeruginosa 3′,3′-cGAMP-activated CapV targets diverse phages and overcomes CBASS inhibitors CBASS-sensitive phages transcribe and replicate their genome CBASS activity limits packaged phage DNA, reducing virion production Summary Cyclic-oligonucleotide-based anti-phage signaling system (CBASS) is an immune pathway that recognizes phage infection and generates cyclic nucleotide signals, which

Highlights Isolated TPD-causing V. parahaemolyticus strain P40.49 from infected shrimp. Experimental infection confirmed the pathogenicity of the TPD-causing strain P40.49. Whole genome sequencing confirmed the presence of ∼69 kbp TPD-associated plasmid. The shrimp stomach and intestine tissues are ideal for early TPD detection (6 hpi). Four unique TPD-associated genes may serve as additional markers for TPD detection. Abstract Emerging infectious diseases threaten shrimp aqu

Highlights W. chondrophila encodes two Ndk paralogs, unlike most Chlamydiota. ndk genes are early expressed and protein levels peak during bacterial replication. WcNdk1 is inclusion-bound, while WcNdk2 localizes to host cell compartments. AZT inhibits bacterial growth and protects host cells from infection-induced death. AZT sensitivity is linked to ndk2 presence, implicating WcNdk2 as functional target. Abstract The Chlamydiota phylum consists of obligate intracellular bacte

Highlights Adjunctive oral FMT accelerates antidepressant response as early as week 2 Superior efficacy persists through 8 weeks with no additional side effects FMT reshapes gut microbes, with donor strains coexisting in recipients Benefits are mediated by elevated bile acids and reduced systemic inflammation Summary Gut microbiota may influence antidepressant treatment outcomes, yet whether targeted modulation can enhance efficacy remains unclear. We conducted a randomized,