Highlights Virome functions as an independent regulator of small intestinal nutrient sensing Virome elicits distinct responses across different intestinal cell types Virome regulation of carbohydrate sensing depends on immune surveillance Summary The enteric microbiome and nutrient sensing within the small intestine play critical roles in maintaining host metabolic homeostasis. Although various bacteria and some fungi have established functions in nutrient metabolism, the rol

Highlights SCFAs function as gut-derived epigenetic regulators, bridging dietary fiber metabolism to brain-wide chromatin remodeling in neurodegenerative diseases. Butyrate acts as a potent HDAC inhibitor, enhancing histone acetylation to suppress neuroinflammation and promote synaptic plasticity in AD and PD models. SCFAs modulate DNA methylation dynamics via TET-DNMT balance, correcting aberrant gene expression linked to Aβ and α-synuclein pathologies. Emerging evidence pos

Highlights Reconstructed and curated of the genome-scale metabolic model (GEM) of  Fusobacterium nucleatum Experimental data used to refine and validate the GEM, including biomass formulation with BOFdat (Biomass Objective Function from experimental data) Integrated transcriptomic data to build context-specific metabolic models Metabolic rewiring links  F. nucleatum  adaptation to colorectal cancer (CRC) context Provides a systems framework to explore host-microbe metabolic i

Highlights A novel virus system rEBV-VSV was developed realizing efficient and native EBV entry via multi-synergetic glycoproteins with sensitive bioluminescence detection. rEBV-VSV was especially competent for rapid and high-throughput entry-inhibition evaluation of drugs, antibodies, or sera and accurate study of EBV entry mechanisms via flexible mutations or recombination on rEBV-VSV. Glycoprotein 42 (gp42) was found to mediate diverse functions of an important mutation L6