Highlights Reconstructed and curated of the genome-scale metabolic model (GEM) of  Fusobacterium nucleatum Experimental data used to refine and validate the GEM, including biomass formulation with BOFdat (Biomass Objective Function from experimental data) Integrated transcriptomic data to build context-specific metabolic models Metabolic rewiring links  F. nucleatum  adaptation to colorectal cancer (CRC) context Provides a systems framework to explore host-microbe metabolic i

Highlights A novel virus system rEBV-VSV was developed realizing efficient and native EBV entry via multi-synergetic glycoproteins with sensitive bioluminescence detection. rEBV-VSV was especially competent for rapid and high-throughput entry-inhibition evaluation of drugs, antibodies, or sera and accurate study of EBV entry mechanisms via flexible mutations or recombination on rEBV-VSV. Glycoprotein 42 (gp42) was found to mediate diverse functions of an important mutation L6

Highlights Genome catalog of 4,098  B. infantis  and  B. longum  shows distinct biogeography and ecology B. infantis  is depleted in Westernized populations but highly common in LMIC infants Massively expanded  B. infantis  diversity and functions are absent from current probiotics Geo-specific strain library informs diet- and population-tailored infant probiotic design Summary Bifidobacterium longum  and  B. infantis  are pioneer colonizers of the neonatal gut and are widely

D EMENTIA IS tragically  common among the elderly. In 2021 57m people worldwide were thought to have the condition. Ageing is a risk factor for many other ailments too, ranging from chronic inflammation to a decline in organ function. A growing body of work, however, suggests that simply taking a course of the shingles vaccine can meaningfully slow the decline. The new data, from a range of countries, suggests that it cuts risk by 20%. Shingles is a painful skin condition cau