Highlights The global regulator ppGpp plays a central role in controlling AIEC virulence. Loss of ppGpp impairs virulence across in vitro and in vivo infection models. Two candidate biomarkers with discriminatory potential for AIEC identification were defined. Abstract Strain LF82 belongs to the Adherent-Invasive Escherichia coli (AIEC) pathotype, found in 21% to 63% of Crohn’s disease (CD) patients. Many studies have explored its specific virulence mechanisms, but AIEC isola

People who live together share more oral and gut microbes with each other than with other people in their communities, according to a study published June 15, 2026, in the Cell Press journal Cell Press Blue. This was true regardless of the cohabitants’ relationships—siblings, parents, and offspring all shared similar numbers of microbial strains, and romantic partners shared even more oral (but not gut) microbes with each other, likely due to kissing. The research, covered in

Abstract Pit mud (PM) microbiota play a vital role in Baijiu flavor formation, yet its ecological and functional succession during maturation remains incompletely elucidated. Here, physicochemical profiling, amplicon sequencing, and metagenomics were integrated to investigate 5-, 15-, and 30-year PM of Sichuan Tang Dynasty Laojiao cellars. Bacteria dominated the community (82.59%), followed by Archaea (16.99%), with Lactobacillus acetotolerans, Ruminococcaceae CPB6, and Metha

Highlights Microbial pantothenic acid (PA) supply is reduced in individuals with MetS panC enables B. fragilis to supply PA to the colonic microenvironment B. fragilis PA biosynthesis preserves the gut barrier and alleviates MetS Microbial PA sustains KLF4 via the PANK2/3-CoA axis to support differentiation Summary Pantothenic acid (PA), or vitamin B5, can be synthesized by gut commensals, but the contribution of microbial PA to metabolic health remains unclear. Here, we find