Highlights Administration of the bacteriophage cocktail at a high MOI reduced APEC-induced morbidity and mortality by 20-30% in laying hens, validating its potential as an antimicrobial alternative. The oral route (drinking water) demonstrated superior therapeutic efficacy compared to intramuscular injection, resulting in the complete absence of macroscopic lesions and a noticeable reduction in median histopathological scores, particularly in the spleen. The administered phag

A  sexually transmitted infections  ( STI ) is a  disease  which  spreads  by having  sex . STIs can spread through  oral sex  or  anal sex , or when two people's  genitals  touch. STIs can be caused by  viruses ,  bacteria , or  parasites . Examples of the most common STIs are listed on this page. Types of STDs STIs caused by viruses Human Immunodeficiency Virus (HIV) Main article:  Human immunodeficiency virus HIV causes the  immune system  - the system in the body that is

Highlights Meta-analysis of 11,115 gut metagenomes links uncultured species to human health Healthy individuals show enrichment and greater diversity of uncultured bacteria The genus CAG-170 contains uncultured taxa with the strongest health signatures CAG-170 is ecologically important in healthy populations Summary The human gut microbiome is important for host health, yet over 60% of gut species remain uncultured and inaccessible to experimental manipulation. Here, we analy

Highlights Severe IAV infection imparts a long-lasting decline in cardiac function Atypical GMP-independent CD319+ pro-DC3s transport infectious IAV to cardiomyocytes Direct IFN-I signaling on cardiomyocytes drives cardiac dysfunction mod-mRNA delivery of dominant-negative IFNAR1 on cardiomyocytes ameliorates damage Summary Abundant evidence has correlated influenza infection with cardiovascular disease, yet mechanisms linking infection with the heart remain poorly understood