Highlights Sesame-flavor Baijiu fermentation was performed using different sorghum varieties. Microbial interactions affected volatile formation differently in sorghum varieties. Cultivar-specific physicochemical traits modulate microbial consortia structure. Sorghum selection can format flavor paradigm and standardize Baijiu quality. Abstract Sorghum is a key raw ingredient in the fermentation of Sesame-flavor Baijiu (SFB). However, studies on the microbial and metabolic dyn

Highlights This study systematically analyzed alterations in the ocular surface microbiome of patients with progressive supranuclear palsy-Richardson’s syndrome (PSP-RS) via metagenomic sequencing, with comparisons to Parkinson’s disease (PD) patients and healthy controls (HC). The β-diversity of the ocular surface microbiome in PSP-RS patients was significantly altered compared to HC, while no such obvious difference was observed in PD patients. PSP-RS patients exhibited inc

Highlights The S. maltophilia MntH importer contributes to H2O2 resistance and intracellular survival The Mn exporter MntP limits toxicity even at sub-inhibitory Mn²⁺ concentrations The S. maltophilia MntR regulated genes include the extracytoplasmic TBDR-pTFP module The TBDR-pTFP locus is specifically induced under combined Mn2+ and Fe2+ limitation S. maltophilia Mn homeostasis is linked to iron availability and oxidative stress responses ABSTRACT Manganese homeostasis is es

Highlights Bifidobacterium stercoris KC84 alleviates IBS-D-like symptoms in mouse and rat models KC84 modulates serotonin-related pathways associated with diarrhea KC84 induces IFN-β production from colonic dendritic cells IFN-β is associated with reduced intestinal smooth muscle contractility Abstract Irritable bowel syndrome with diarrhea (IBS-D) is a prevalent disorder that significantly impairs quality of life, yet therapeutic advances remain limited. Serotonin dysregulat