Highlights Meta-analysis of 11,115 gut metagenomes links uncultured species to human health Healthy individuals show enrichment and greater diversity of uncultured bacteria The genus CAG-170 contains uncultured taxa with the strongest health signatures CAG-170 is ecologically important in healthy populations Summary The human gut microbiome is important for host health, yet over 60% of gut species remain uncultured and inaccessible to experimental manipulation. Here, we analy

Highlights Severe IAV infection imparts a long-lasting decline in cardiac function Atypical GMP-independent CD319+ pro-DC3s transport infectious IAV to cardiomyocytes Direct IFN-I signaling on cardiomyocytes drives cardiac dysfunction mod-mRNA delivery of dominant-negative IFNAR1 on cardiomyocytes ameliorates damage Summary Abundant evidence has correlated influenza infection with cardiovascular disease, yet mechanisms linking infection with the heart remain poorly understood

Highlights Three NlpC/P60 endopeptidases identified in  Deinococcus radiodurans CwlA is essential for cell viability and cell wall integrity CwlB is involved in cell septation whereas CwlC is dispensable Regulatory link between CwlA expression and the genotoxic stress response pathway ABSTRACT The bacterial cell wall is composed of peptidogylcane (PG), a sugar polymer cross-linked by short peptide stems. PG determines cell morphology and protects it from environmental stresse

Highlights We have discovered an alternative mechanism mediated by insoluble dietary fiber that contributes to the prevention of colorectal tumorigenesis, potentially accounting for the paradoxical role of SCFAs. Microbial enzyme encoded by K12373 promotes tumorigenic glycosphingolipid GM3 production, which can be suppressed by high-fiber diet. As a key node in glycosphingolipid metabolism, K12373 directs metabolic flux primarily towards the GM3 branch and, to a lesser extent