Highlights SCFAs function as gut-derived epigenetic regulators, bridging dietary fiber metabolism to brain-wide chromatin remodeling in neurodegenerative diseases. Butyrate acts as a potent HDAC inhibitor, enhancing histone acetylation to suppress neuroinflammation and promote synaptic plasticity in AD and PD models. SCFAs modulate DNA methylation dynamics via TET-DNMT balance, correcting aberrant gene expression linked to Aβ and α-synuclein pathologies. Emerging evidence pos

Highlights Reconstructed and curated of the genome-scale metabolic model (GEM) of  Fusobacterium nucleatum Experimental data used to refine and validate the GEM, including biomass formulation with BOFdat (Biomass Objective Function from experimental data) Integrated transcriptomic data to build context-specific metabolic models Metabolic rewiring links  F. nucleatum  adaptation to colorectal cancer (CRC) context Provides a systems framework to explore host-microbe metabolic i

Highlights A novel virus system rEBV-VSV was developed realizing efficient and native EBV entry via multi-synergetic glycoproteins with sensitive bioluminescence detection. rEBV-VSV was especially competent for rapid and high-throughput entry-inhibition evaluation of drugs, antibodies, or sera and accurate study of EBV entry mechanisms via flexible mutations or recombination on rEBV-VSV. Glycoprotein 42 (gp42) was found to mediate diverse functions of an important mutation L6

Highlights Genome catalog of 4,098  B. infantis  and  B. longum  shows distinct biogeography and ecology B. infantis  is depleted in Westernized populations but highly common in LMIC infants Massively expanded  B. infantis  diversity and functions are absent from current probiotics Geo-specific strain library informs diet- and population-tailored infant probiotic design Summary Bifidobacterium longum  and  B. infantis  are pioneer colonizers of the neonatal gut and are widely