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MOSTLY MICROBES AND INFECTIOUS DISEASES

Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.

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Association between gut microbiota and prediabetes in people living with HIV

The prevalence of prediabetes is rapidly increasing in general population and in people living with #HIV #AIDS (PLWH). Gut microbiota play an important role in human health, and dysbiosis is associated with metabolic disorders and HIV infection. Here, we aimed to evaluate the association between gut microbiota and prediabetes in PLWH. A cross-sectional study enrolled 40 PLWH who were receiving antiretroviral therapy and had an undetectable plasma viral load. Twenty participa

Researchers determined how a genetic mutation found in mice and monkeys interferes with viruses such

Researchers determined how a genetic mutation found in mice and monkeys interferes with viruses such as #HIV & #Ebola. The gene, retroCHMP3, encodes an altered protein that disrupts the ability of the viruses to exit an infected cell & infect other cells. A nationwide team of researchers, led by scientists at University of Utah Health and The Rockefeller University, has determined how a genetic mutation found in mice and monkeys interferes with viruses such as HIV and Ebola.

Multinational Project Launched to Pursue New Strategy for Curing HIV

A multinational project is launched to pursue new strategies for curing #AIDS. The aim will be to both silence & permanently remove #HIV from the body. A global, multi-disciplinary initiative is trying a completely new strategy for curing HIV. The group, known as the HIV Obstruction by Programmed Epigenetics (HOPE) Collaboratory, will be led by researchers at Gladstone Institutes, Scripps Research Florida, and Weill Cornell Medicine. Their approach, which aims to both silence

HIV & AIDS - signs, symptoms, transmission, causes & pathology

What are HIV & #AIDS? (free video) #HIV, or human immunodeficiency virus, is a type of virus that infects human immune cells. Over time, immune cells are lost, which weakens the immune system and allows patients to be infected by other viruses and develop several types of tumors. #virology #virus

'Smart' segmented ring device delivers medications to stop HIV transmission

#AIDS #HIV #hydroxychloroquine #HCQ The device is an intravaginal ring (IVR ) that can be inserted into the female genital tract where it will deliver medications known to decrease the transmission of HIV. Researchers have designed a device that delivers two medications that help stop HIV transmission. Although condom usage is the best strategy for preventing HIV transmission, the researchers are working to design a device that can be used by sex workers and in situations whe

HIV infections in the US have dropped by 73 percent in the past 40 years

#HIV infections in the US have declined by 73% since peaking in the mid-1980s, according to the CDC. But about 13% do not know they have #AIDS and should be tested, says the agency. HIV infections have declined by 73 percent nationwide since peaking in the mid-1980s, according to the Centers for Disease Control and Prevention. New infections numbered 20,000 in 1981, reaching 130,400 in 1984 before declining to 34,800 by 2019, the CDC reported recently. HIV — the human immunod

Skepticism Of Science In A Pandemic Isn't New. It Helped Fuel The AIDS Crisis

Skepticism Of Science Helped Fuel The #HIV / #AIDS Crisis "HIV-AIDS denialism became a persistent phenomenon that resulted in the greatest catastrophe in the history of AIDS, which didn't happen until early 2000s: the death of >330,000 people in South Africa." Read more at: https://www.npr.org/2021/05/23/996272737/skepticism-of-science-in-a-pandemic-isnt-new-it-helped-fuel-the-aids-crisis

Lipopeptide-based pan-CoV fusion inhibitors potently inhibit HIV-1 infection

#AIDS #HIV Class I enveloped viruses, such as human immunodeficiency virus type 1 (HIV-1) and highly pathogenic human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV), have posed serious threats to global public health and economy [1]. Therefore, development of broad-spectrum antivirals is urgently needed. During the fusion process of these class Ι enveloped virus

New combination immunotherapy plus ART expand innate cells critical to controlling HIV

#AIDS #HIV #SIV Researchers have determined a combination #immunotherapy of IL-21 and IFNα when added to antiviral therapy (ART) is effective in generating highly functional NK cells that can help control and reduce simian immunodeficiency virus (#SIV) in animal models. ART is the current leading treatment for HIV/AIDS. It is capable of reducing the virus to undetectable levels, but is not a cure and is hampered by issues such as cost, adherence to medication treatment plan a

Getting to the core of HIV replication

#HIV #AIDS Supercomputer simulations supported by the National Science Foundation-funded Extreme Science and Engineering Discovery Environment (XSEDE) have helped uncover the mechanism for how the HIV-1 virus imports into its core the nucleotides it needs to fuel DNA synthesis, a key step in its replication. It's the first example found where a virus performs an activity such as recruiting small molecules from a cellular environment into its core to conduct a process benefici

What are HIV & AIDS? (free video)

HIV, or human immunodeficiency virus, is a type of virus that infects primarily human immune cells. Over time, immune cells are lost, which weakens the immune system and allows patients to be infected by other viruses and develop several types of tumors. #HIV #AIDS #virology

Global Causes Of Death: Significant Shifts From 2000 To 2019

Coronary heart disease and stroke are the two leading causes of death for Homo sapiens on planet Earth, according to a new report from the World Health Organization. This fact has remained unchanged for the past two decades. But this analysis of global deaths over the past 20 years finds significant shifts in how people die — as well as dramatic differences in what leads to death in different regions. Noncommunicable diseases such as dementia and diabetes are now claiming mor

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