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Getting to the core of HIV replication


Supercomputer simulations supported by the National Science Foundation-funded Extreme Science and Engineering Discovery Environment (XSEDE) have helped uncover the mechanism for how the HIV-1 virus imports into its core the nucleotides it needs to fuel DNA synthesis, a key step in its replication. It's the first example found where a virus performs an activity such as recruiting small molecules from a cellular environment into its core to conduct a process beneficial for its life cycle.





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