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MOSTLY MICROBES AND INFECTIOUS DISEASES

Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.

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Antibiotic Resistance Found Deep in Forests of Scandinavia

A DNA analysis of wild brown bear teeth shows that the #AntibioticResistance threat has spread to remote areas of Sweden. Antibiotic resistance is described as “one of the biggest threats to global health, food security and development today” by the World Health Organization. It has spread to humans around the globe—and even wildlife deep in the forest. Scientists says this medical condition—which occurs when bacteria changes in response to the medicines used to treat infecti

Hydrogen sulfide critical to innate ability of bacteria to survive antibiotics

#antibiotics #antibiotictolerance #antibioticresistance The signaling molecule hydrogen sulfide (H2S) plays a critical role in antibiotic tolerance, the innate ability of bacteria to survive normally lethal levels of antibiotics, a new study finds. Published online in the journal Science on June 11, the study revolves around tolerance, wherein bacteria in general have evolved to use common defense systems to resist antibiotics. Tolerance differs from antibiotic resistance, wh

Trained viruses prove more effective at fighting antibiotic resistance

#antibioticresistance #phages #bacteriophages #microbiology #evolution Scientists trained phages to lead to greater bacterial suppression & delay evolution of phage resistance. The threat of antibiotic resistance rises as bacteria continue to evolve to foil even the most powerful modern drug treatments. By 2050, antibiotic resistant-bacteria threaten to claim more than 10 million lives as existing therapies prove ineffective. Bacteriophage, or "phage," have become a new sourc

Global travelers pick up numerous genes that promote microbial resistance

#antibiotics #antibioticresistance #microbiome #microbiota Such genes have potential to spread when travelers return home Carried like stowaways in the guts of international travelers, new and potentially deadly strains of antimicrobial resistant superbugs may be coming to a community near you, suggests new research from Washington University School of Medicine in St. Louis. "Even before the COVID-19 pandemic, we knew that international travel was contributing to the rapid gl

Environmental antibiotics and resistance genes as emerging contaminants

#bioremediation #environment #microbiology #antibiotics #AntibioticResistance In developing countries, the use of antibiotics has helped to reduce the mortality rate by minimizing the deaths caused by pathogenic infections, but the costs of antibiotic contamination remain a major concern. Antibiotics are released into the environment, creating a complicated environmental problem. Antibiotics are used in human, livestock and agriculture, contributing to its escalation in the e

Environmental antibiotics and resistance genes as emerging contaminants

#AntibioticResistance #bioremediation #environment #antibiotics In developing countries, the use of #antibiotics has helped to reduce the mortality rate by minimizing the deaths caused by pathogenic infections, but the costs of antibiotic contamination remain a major concern. Antibiotics are released into the environment, creating a complicated environmental problem. Antibiotics are used in human, livestock and agriculture, contributing to its escalation in the environment. E

Antibiotic resistance in agriculture: strategies to overcome upsurge in resistance

#AntibioticResistance is a massive problem rising constantly and spreading rapidly since the past decade. The major underlying mechanism responsible for this problem is an overuse or severe misuse of antibiotics. Regardless of this emerging global threat, antibiotics are still being widely used, not only for treatment of human infections, but also to a great extent in #agriculture, livestock and animal husbandry. If the current scenario persists, we might enter into a post-an

'Superbugs' kill more than 35K Americans each year. Doctors to blame?

#AntibioticResistance #antibiotics As the medical community develops treatments to combat the coronavirus, another deadly enemy continues to lurk in hospitals across the country: antibiotic-resistant infections. The Centers for Disease Control and Prevention calls antibiotic resistance one of the “biggest public health challenges of our time,” and a new study suggests doctors may be partially to blame for its prevalence. The study found more than half of antibiotics prescribe

New study shows microplastics turn into 'hubs' for pathogens, antibiotic-resistant bacteria

Microplastics can become 'hubs' for antibiotic-resistant bacteria to grow once they wash down household drains & enter wastewater treatment plants, forming a biofilm on their surface that allows pathogens & antibiotic waste to attach & comingle. #plastics #plastic #environment #microbiology #AntibioticResistance https://phys.org/news/2021-03-microplastics-hubs-pathogens-antibiotic-resistant-bacteria.html

Bacteria Have Been Seen Literally Changing Shape to Avoid Antibiotics

Scientists discover a simple new way bacteria (Caulobacter crescentus) avoid #antibiotics in the human body - by changing shape. Upon antibiotic removal, cells recover their original forms. #antibioticresistance https://www.sciencealert.com/bacteria-can-change-shape-to-help-them-become-more-resillient-to-antibiotics

Where antibiotic resistance comes from

By comparing 1000s of bacterial genomes, scientists have traced back the evolutionary history of #AntibioticResistance genes. In almost all cases where an origin could be determined, the gene started to spread from bacteria that can cause disease. https://phys.org/news/2021-01-antibiotic-resistance.html

When a Virus Is the Cure

In the past five years, bacteriophage research has accelerated, with a proliferation of publications, conferences, and pharmaceutical-company investment. This enthusiasm reflects the ever-growing threat of antibiotic-resistant bacteria and a dearth of new antibiotics available to fight them. #bacteriophage #phage #microbiology #antibiotics #antibioticresistance https://www.newyorker.com/magazine/2020/12/21/when-a-virus-is-the-cure

Paper-Based Device Rapidly Detects Antibiotic-Resistant Bacteria

Researchers developed a device that can rapidly detect certain types of antibiotic-resistant bacteria. The device uses paper as a substrate, & allows a user to rapidly test the effects of specific antibiotics on patient bacterial samples. #antibioticresistance #antibiotics https://www.medgadget.com/2020/12/paper-based-device-rapidly-detects-antibiotic-resistant-bacteria.html

The book reopened on infectious diseases

Emerging infectious diseases represent a major challenge to human health worldwide. The risk of evolving new infectious pathogens has been intensifying due to urbanization, demographic changes, air travel, inappropriate use of antibiotics, and climate change. These pathogens can affect humans from urban centers to the remotest corners of the globe. Far from being a scourge of the past, infectious diseases are relevant for the world today. #microbes #infection #emergingpathoge

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