First‑Line Fecal Microbiota Transplantation Shows Rapid Efficacy in Immune Checkpoint Inhibitor–Induced Colitis

First‑line fecal microbiota transplantation yields rapid improvement in most patients with immune checkpoint inhibitor–mediated colitis. In this cohort, 76.9% responded within a median 1.5 days, with increased microbial diversity and reduced immune‑cell activation after treatment. Multi‑omics profiling highlights potential mechanisms underlying FMT response.

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https://www.sciencedirect.com/science/article/pii/S2666379126004611