Melatonin‑Responsive PfSR1‑MT Identified as a GPCR‑Like Target in the human malaria parasite Plasmodium falciparum
Researchers identify PfSR1‑MT as a melatonin‑responsive GPCR‑like receptor in Plasmodium falciparum. PfSR1‑MT binds melatonin with high affinity, triggers ECD movement and Ca²⁺ signaling, and is selectively activated by ARL34, which inhibits parasite growth and gametocyte development, highlighting a promising antimalarial target.
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