SCFA‑Producing Gut Commensals as Regulators of Alzheimer’s Neuroinflammation
SCFA‑producing gut bacteria are depleted in Alzheimer’s disease, weakening microbiota‑gut‑brain axis control of neuroinflammation. SCFAs shape microglial and astrocytic states, suppress NLRP3 activation, and influence amyloid, tau, and synaptic integrity. The review evaluates dietary, probiotic, postbiotic, and FMT strategies and outlines biomarker‑guided, personalized therapeutic approaches.
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