Senolytics combat COVID-19 in aging
#aging increases vulnerability to respiratory viral infections, including by #SARSCoV2. Delval et al. established a causal role for...
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MOSTLY MICROBES AND INFECTIOUS DISEASES
Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.
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Parabacteroides distasonis uses dietary inulin to suppress NASH via pentadecanoic acid
Study shows that gut #microbiota members can use dietary fibre to generate beneficial metabolites to suppress metabolic disease....
Pacific has one of most successful years for grants in school history
University of the Pacific secured 62 grants from federal, state and county agencies totaling more than $36 million—one of the best years...
Hunter-gatherer lifestyle fosters thriving gut microbiome
Sequencing the #microbiome of hunter-gatherers & city-dwellers shows that Western lifestyle decreases diversity of gut-bacteria...
Researchers uncover a cellular process that leads to inflammation
Cedars-Sinai investigators have identified several steps in a cellular process responsible for triggering one of the body's important...
Negative Regulatory NLRs Mitigate Inflammation via NF-κB Pathway in Inflammatory Bowel Disease
A subset of NLRs function to mitigate overzealous pro-inflammatory signaling produced by NF-κB activation. Under normal pathophysiologic...
Taurine deficiency as a driver of aging
Studying various animals, a study found that the amount of the semi-essential amino acid #taurine in circulation decreased with age....
Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes
Gut #microbiota influence host immunity and metabolism during obesity. Bacterial sensors of the innate immune system relay signals from...
In China (and elsewhere), an Unseen & Dangerous Foe Takes Root: Lethal Fungi.
Rising temperatures & ecosystem disturbances are creating a hotbed for fungi that can spark hard-to-treat infections in peoples’ lungs,...
Oral Microbiome and Health
Guest editors: Ozlem Yilmaz and David Ojcius. There is growing awareness that microbes in the oral cavity have a large effect on both...
Centenarians have diverse gut virome w/ potential to modulate metabolism & promote healthy lifespan
Compared with viromes of young adults (>18 yr) & old people (>60 yr), centenarians have diverse #virome including previously undescribed...
The oral microbiota: living with a permanent guest
by Maria Avila, David M Ojcius, Ozlem Yilmaz. The oral cavity of healthy individuals contains hundreds of different bacterial, viral, and...
Infection of the oral cavity with SARS-CoV-2 variants: Scope of salivary diagnostics
Coronaviruses, including #SARSCoV2, have caused pandemics in the past two decades. The most prevalent SARS-CoV-2 variants of concern can...
David Ojcius Discusses The Association Between Oral Health And Systemic Disease
David Ojcius is the assistant dean of research and the chair of the Biomedical Sciences department at the University of the Pacific....
Dicer regulates activation of the NLRP3 inflammasome
by David M. Ojcius, Ardavan Jafari, Laxmi Yeruva, Christian W. Schindler, Ali A. Abdul-Sater Inflammation plays a critical role in...
What SuperAgers show us about longevity, cognitive health as we age
· Eat like a centenarian by incorporating fiber-rich foods into your diet. · Exercise your body. · #Exercise your brain. · Stay...
Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures
Centenarians display youth-associated features in gut #microbiome such as over-representation of #Bacteroides-dominated enterotype,...
Intermittent fasting modulates gut microbiota and improves obesity and host energy metabolism
A small study in humans found that #IntermittentFasting modulates the intestinal #microbiota & improves #obesity & host energy...
Beta lactamase-producing Neisseria gonorrhoeae alleviates Amoxicillin-induced chlamydial persistence
Highlights • #Chlamydia trachomatis (CT) and $Neisseria gonorrhoeae (NG) co-infections are common. • N. gonorrhoeae may cause a...
Probiotic supplements may do the opposite of boosting your gut health
In healthy people, #probiotic supplements offer little benefit & can potentially do more harm than good. Studies show that taking...
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