Plasmid-Associated Camptothecin Transformation in Plant-Associated Sphingobium Bacteria
Researchers investigated how rhizosphere-associated Sphingobium bacteria adapt to the camptothecin-rich environment of Ophiorrhiza pumila. They discovered selective transformation of camptothecin analogs and linked this capability to a plasmid-borne accessory module enriched in oxidative, transport, regulatory, and ring-cleavage functions, providing insight into microbial adaptation to specialized plant metabolites.
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