C2H2 Zinc Finger Regulator MrhbtA Enhances Fungal Morphology and Monascus Azaphilone Biosynthesis
Researchers uncovered the regulatory role of MrhbtA in coordinating fungal development and secondary metabolism in Monascus ruber. DAP-seq identified 121 target genes, including key regulators of cell wall remodeling and cell division. The findings establish MrhbtA as a master regulator linking hyphal architecture to enhanced biosynthesis of commercially important Monascus azaphilone pigments.
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