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Effects of microbiota-derived metabolites on neuroinflammation in multiple sclerosis

#microbiota #inflammation #microbiome #neuroscience


Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) are highly influenced by changes in the microbiota and of microbiota-derived metabolites, including short chain fatty acids, bile acids, and tryptophan derivatives. This review will discuss the effects of microbiota-derived metabolites on neuroinflammation driven by central nervous system-resident cells and peripheral immune cells, and their influence on outcomes of EAE and MS.





https://www.sciencedirect.com/science/article/pii/S1286457921000368#fig5

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