Researchers found that 1'-acetoxychavicol acetate (ACA), which comes from tropical ginger, attenuates mitochondrial damage by decreasing mitochondrial reactive oxygen species (ROS) & blocking activation of the NLRP3 inflammasome.
Many natural compounds have various anti-inflammatory and other beneficial properties that humans have been utilizing for medicinal purposes for hundreds of years. However, the specific molecular mechanisms behind these health-promoting effects are not always clear. One such compound is 1'-acetoxychavicol acetate, or ACA, which comes from the tropical ginger Alpinia plant. Now, researchers from Nara Institute of Science and Technology (NAIST) have identified how ACA can help in the treatment of inflammatory diseases.
In a report published in International Immunology, they found that ACA attenuates mitochondrial damage through decreasing mitochondrial reactive oxygen species (ROS), blocking activation of a crucial protein complex known as the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome. Many inflammatory diseases, like inflammatory bowel disease, display improper and chronic activation of this complex.