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Welcome to Mostly Microbes and Infectious Diseases. David Ojcius posts newspaper and journal articles in the broad field of microbiology.

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Senolytics reduce coronavirus-related mortality in old mice

#senescence #COVID19 #coronavirus #aging #inflammation Targeting senescent cells using senolytic drugs before or after coronavirus exposure significantly reduced mortality, cellular senescence, & inflammatory markers & increased anti-viral antibodies in old mice. The COVID-19 pandemic has revealed the pronounced vulnerability of the elderly and chronically-ill to SARS-CoV-2-induced morbidity and mortality. Cellular senescence contributes to inflammation, multiple chronic dise

Humans Could Live Up to 150 Years, New Research Suggests

#aging #longevity #resilience Researchers have taken on the question of how long we can live if, by some combination of serendipity and genetics, we do not die from cancer, heart disease or getting hit by a bus. They report that when omitting things that usually kill us, our body’s capacity to restore equilibrium to its myriad structural and metabolic systems after disruptions still fades with time. And even if we make it through life with few stressors, this incremental decl

Ganoderma lucidum stimulates autophagy-dependent longevity pathways in C. elegans and human cells

#lingzhi #reishi #aging #longevity #traditionalmedicine The medicinal fungus Ganoderma lucidum is used as a dietary supplement and health tonic, but whether it affects longevity remains unclear. We show here that a water extract of G. lucidum mycelium extends lifespan of the nematode Caenorhabditis elegans. The G. lucidum extract reduces the level of fibrillarin (FIB-1), a nucleolar protein that correlates inversely with longevity in various organisms. Furthermore, G. lucidum

People who live past 105 years old have genes that stop DNA damage

#DNA #aging #longevity #DNARepair People who reach a very old age may have their genes to thank. Genetic variants that help to prevent DNA mutations and repair any that do occur have been found in supercentenarians and semi-supercentenarians – people who reach the ages of 110 and 105, respectively. “DNA repair mechanisms are extremely efficient in these people,” says Claudio Franceschi at the University of Bologna in Italy. “It is one of the most important basic mechanisms f

The central role of DNA damage in the aging process

#Aging is a complex, multifaceted process leading to widespread functional decline that affects every organ and tissue, but it remains unknown whether ageing has a unifying causal mechanism or is grounded in multiple sources. Phenotypically, the ageing process is associated with a wide variety of features at the molecular, cellular and physiological level—for example, genomic and epigenomic alterations, loss of proteostasis, declining overall cellular and subcellular function

Anti-aging compound improves muscle glucose metabolism in people

A natural compound (#NMN, nicotinamide mononucleotide) previously demonstrated to counteract aspects of #aging & improve #glucose metabolism & metabolic health in mice has clinically relevant effects in people, according to new research

7 healthy habits to slow aging, shared by a longevity expert.

7 healthy habits to slow aging, shared by a #longevity expert. You have more control over your #aging process than you realize, says Andrew Steele, author of "Ageless" Andrew Steele envisions a future where people no longer become elderly — staying fit and disease-free for longer. Society should “unashamedly aim to cure aging” with treatments that could slow down the accumulation of mutations in our DNA or problems that happen with our mitochondria, the London-based scienti

The first non-invasive biomarker to track and verify efficacy of senolytic drugs

#senescence #aging Researchers have discovered a novel, non-invasive biomarker (15-deoxy-delta-12, 14-prostaglandin J2; dihomo-15d-PGJ2) that can be used to measure & track performance of senolytics: a class of drugs that selectively eliminate senescent cells.

Chronic viral infections can have lasting effects on human immunity, similar to aging

Research suggests that chronic #viral infections have a profound & lasting impact on the human immune system in ways that are similar to those seen during #aging. Using systems #immunology and #artificialintelligence, researchers profiled and compared immune responses in a cohort of aging individuals, people with HIV on long-term anti-retroviral therapy, and people infected with hepatitis C (HCV) before and after the virus was treated with a drug that has up to a 97% cure rat

Tips to fight aging, live healthier.

A 2018 study found that people who followed five habits (eating a healthy diet, exercising regularly, keeping a healthy body weight, not drinking excessive amounts of alcohol and not smoking) increased life expectancy by up to 10 years. #aging #healthyaging

A Changing Gut Microbiome May Predict How Well You Age

The secret to successful aging may lie in part in your gut, according to a new report. The study found that it may be possible to predict your likelihood of living a long and healthy life by analyzing the trillions of bacteria, viruses and fungi that inhabit your intestinal tract. The new research, published in the journal Nature Metabolism, found that as people get older, the composition of this complex community of microbes, collectively known as the gut #microbiome, tends

Physicians and scientists join forces to develop the longevity medicine curriculum

Physicians and scientists highlight the importance of #longevity medicine education and collaborate on the first longevity medicine course for physicians Longevity medicine is a rapidly evolving branch of preventative #precisionmedicine that is specifically focused on promoting healthspan and lifespan, utilizing #aging biomarkers commonly referred to as aging clocks. Over the past decade advances in AI and machine learning enabled the development of deep aging clocks (DACs) a

Book review of "Ageless" by Andrew Steele

A hopeful message for all those facing the prospect of old age (that is, everyone). Old age needn’t be a massacre - in fact, old age needn’t even be old. #aging #Ageless

What really works to help an aging brain.

What really works to help an aging brain. It’s not going to function like it did in your 20s, but there are things you can do. What works: Exercising, eating well, learning a language, staying mentally & socially engaged. #aging #exercise #diet

For breakthroughs in slowing aging, scientists must look beyond biology

For breakthroughs in slowing #aging, scientists must look beyond biology. Stress & early life adversity, personality traits, intelligence, social connection & purpose in life need to be taken into account to get a meaningful prediction of human biological aging

Gut microbiome implicated in healthy aging and longevity

The gut #microbiome is an integral component of the body, but its importance in the human #aging process is unclear. Scientists have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn predict survival in a population of older individuals. Gut microbiomes become increasingly unique as individuals age, starting in mid-to-late adulthood, which corresponds with a steady decline in abundance o

NAD+ can restore age-related muscle deterioration, research finds

Alzheimer's-like protein aggregates are found in the muscle deterioration seen in aging, but the aggregates can be reversed by boosting the levels of NAD+, which turns on the defense systems of mitochondria in cells & restores muscle function. #aging #metabolism #biochemistry

Inhibiting glutaminolysis in mice found to eliminate senescent cells

Researchers found that inhibiting kidney-type glutaminase-dependent glutaminolysis in mice can lead to elimination of #senescent cells. Senescent cells play a role in development of #aging-related diseases such as arteriosclerosis & muscle degeneration.

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