Glutamine has a host of metabolic functions, including biosynthesis, redox maintenance, and chromatin biology. Drugs are currently available to target glutamine and related metabolism. However, the use of these compounds has been limited by finding appropriate applications because the role of #glutamine in health and disease is still poorly understood. Some studies have pointed to a limited role of glutamine #metabolism in vivo; others have found specific roles in critical ar

If you feel like you’re slowing down a bit as you age, you’re not alone. Many of our systems (including our brain) tend to taper off as we get older and the immune system is no exception. #aging #immunology https://davidojcius.com/immunology-research-professor-david-ojcius-explains-the-effects-of-aging-on-our-immune-system/

Researchers conducted genome-wide #CRISPR-based screens in premature aging stem cells & identified >100 candidate #senescence-promoting genes. Among them, KAT7 (a histone acetyltransferase) was identified as a top target involved in cellular senescence. #aging #longevity Figure below: Gene therapy targeting Kat7 extends lifespan in naturally aged and progeria mice. https://medicalxpress.com/news/2021-01-scientists-gene-therapy-strategy-aging.html

Caloric restriction (CR) mimetics are molecules that produce beneficial effects on health and longevity in model organisms and humans, without the challenges of maintaining a CR diet. Conventional CR mimetics such as metformin, rapamycin and spermidine activate autophagy, leading to recycling of cellular components and improvement of physiological function. We review here novel CR mimetics and anti-aging compounds, such as 4,4′-dimethoxychalcone, fungal polysaccharides, inorg

Caloric restriction (CR) mimetics are molecules that produce beneficial effects on health and longevity in model organisms and humans, without the challenges of maintaining a CR diet. Conventional CR mimetics such as metformin, rapamycin and spermidine activate autophagy, leading to recycling of cellular components and improvement of physiological function. We review here novel CR mimetics and anti-aging compounds, such as alpha-ketoglutarate, 4,4'-dimethoxychalcone, fungal p

#aging patients still should have an annual “wellness” visit to check blood pressure, blood sugar (for the presence of Type 2 #diabetes), cholesterol, bone density (for #osteoporosis), #obesity and underweight (for frailty), skin (for cancerous lesions), #hearing, #vision and balance (to evaluate the risk of falls), and cognition. They also should keep up with certain #vaccinations, such as flu, shingles, tetanus and pneumonia. But they might be able to avoid certain tests if

If you feel like you’re slowing down a bit as you age, you’re not alone. Many of our systems (including our brain) tend to taper off as we get older and the immune system is no exception. #aging #immunology #inflammation #senescence https://davidojcius.com/immunology-research-professor-david-ojcius-explains-the-effects-of-aging-on-our-immune-system/

#microbiology #immunology #microbes #infection #aging #longevity #biomedical https://thriveglobal.com/stories/david-ojcius-on-lifelong-learning-as-a-researcher/…

Senescent cells promote NAD tissue decline during aging through CD38 enzymes which can now become a novel therapeutic target. #inflammation #aging #longevity #senescence #immunology Nicotinamide adenine dinucleotide (NAD) is a crucial metabolic coenzyme and reducing cofactor for oxidising enzymes such as poly-ADP-ribose polymerases (PARPs). Low levels of NAD have been linked to aging diseases and more recently it has been established that natural NAD levels decrease with age